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Opana ER (extended-release oxymorphone) is a powerful opioid used to manage severe chronic pain. It works by binding to opioid receptors in the brain, altering the perception of pain. Opana ER is designed for around-the-clock treatment of pain and is not intended for occasional use. Due to its potency and risk for addiction, it is generally prescribed only when other pain medications have failed. Common side effects include nausea, constipation, drowsiness, and dizziness. Because of its high risk for abuse, Opana ER should be taken under strict medical supervision.